56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,56-54-2
Example 6 (S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid, Quinidine Salt (XXVIII) (rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid THF-solvate (XXVI) (555 g, 0.910 mol) was prepared at 20 C. in butyl acetate (2.22 l) and combined with (+)-quinidine (334.3 g; 1.03 mol). Heating was then done to 50 C. and stirring for 1 h at 50 C. After cooling to 5 C., filtering was done and the filter cake was stirred with butyl acetate (1.2 l), filtered again, and washed with butyl acetate (0.7 l). Drying was done at 40 C. in vacuum. Yield: 361 g (45% of theory) of a cream-colored solid. 1H-NMR (400 MHz, DMSO-d6): delta=1.58 (m, 2H), 1.79 (m, 1H), 2.04 (m, 1H), 2.07 (s, 3H), 2.33 (m, 1H), 2.77 (s, 3H), 2.79 (m, 1H), 2.90 (m, 2H), 3.21 (m, 1H), 3.33 (m, 2H), 3.51 (s, 3H), 3.90 (s, 3H), 5.11 (d, 1H), 5.14 (d, 1H), 5.53 (br. s, 1H), 6.09 (ddd, 1H), 6.72 (s, 1H), 7.75 (m, 2H), 7.82 (m, 1H), 7.92 (br. s, 1H), 8.11 (br. d, 1H), 8.27 (d, 1H), 8.46 (s, 1H), 12.75 (br. s, 1H).
56-54-2 (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol 637552, acatalyst-ligand compound, is more and more widely used in various.
Reference£º
Patent; pH Pharma, Ltd.; Schirmer, Heiko; Rubenbauer, Philipp; Keil, Birgit; Olenik, Britta; (29 pag.)US2018/72685; (2018); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI