With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.,787-70-2
In a typical preparation, a solid mixture of H2BPDC (H2BPDC = 4,4′-biphenyldicarboxylic acid; 0.1039 g, 0.4 mmol), BPY (BPY = 4,4′-bipyridine; 0.033 g, 0.2 mmol), and Cu(NO3)2.3H2O (0.105 g, 0.4 mmol) was dissolved in a mixture of DMF (DMF = N,N’-dimethylformamide; 30 mL), pyridine (0.3 mL), and methanol (3 mL). The resulting solution was stirred at 70 C for 5 min, and then distributed to four 20 mL vials. The vials were then heated at 120 C in an isothermal oven for 24 h. After cooling the vials to room temperature, the solid product was removed by decanting with mother liquor and washed in DMF (3 * 10 mL) for 3 days. Solvent exchange was carried out with methanol (3 * 10 mL) at room temperature for 3 days. The material was then evacuated under vacuum at 140 C for 6 h, yielding 0.103 g of Cu2(BPDC)2(BPY) in the form of blue crystals (67.5% based on copper nitrate).
The synthetic route of 787-70-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Le, Hanh T.N.; Nguyen, Tung T.; Vu, Phuong H.L.; Truong, Thanh; Phan, Nam T.S.; Journal of Molecular Catalysis A: Chemical; vol. 391; 1; (2014); p. 74 – 82;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI