78902-09-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78902-09-7,2-(2,2-Diethoxyethyl)isoindoline-1,3-dione,as a common compound, the synthetic route is as follows.
2-{2-ethoxy-2-[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]ethyl}-1H-isoindole-1,3(2H)-dione (Compound 42) To 50 ml dichloromethane solution of 2-(2,2-diethoxyethyl)-1H-isoindole-1,3(2H)-dione (6.8 g, 25.8 mmol) under an ice bath was added 2,6-lutidine (9.89 mL, 85 mmol) and TMSOTf (10.3 mL, 56.8 mmol). The reaction stirred under the ice bath for one hour. After which, (9Z,12Z)-octadeca-9,12-dien-1-ol (24.3 mL, 77 mmol) was added in and the reaction was stirred from 0 C. to 20 C. for 16 hours. The reaction was diluted with 200 mL dichloromethane and washed by 100 mL of NaHCO3 solution, water, brine. The organic was dried over Na2SO4, filtrated and purified by silica gel chromatography (0% ethyl acetate/hexane?18% ethyl acetate/hexane) to give title compound (12.1 g). MS 506.5 (M+Na).
The synthetic route of 78902-09-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SIRNA THERAPEUTICS, INC.; Colletti, Steven L.; Deng, Zhengwu James; Stanton, Matthew G.; Wang, Weimin; Hills, Ivory; (47 pag.)US9670487; (2017); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI