The author of 《Comparing Industrial Amination Reactions in a Combined Class and Laboratory Green Chemistry Assignment》 were Obhi, Nimrat K.; Mallov, Ian; Borduas-Dedekind, Nadine; Rousseaux, Sophie A. L.; Dicks, Andrew P.. And the article was published in Journal of Chemical Education in 2019. Synthetic Route of C51H42O3Pd2 The author mentioned the following in the article:
This article describes a comparative assignment developed for a third-year undergraduate organic synthesis course involving a combined laboratory experiment and class exercise. In this assignment, students compare the sustainability of two industrial amination reactions to form the same target mol. (4-(n-hexylamino)benzonitrile): a nucleophilic aromatic substitution procedure (SNAr) provided in the class exercise, and a Buchwald-Hartwig (B-H) amination procedure completed in the laboratory The assignment is structured using a “”case-study”” format to provide appropriate context. Students use industrial solvent and reagent substitution guides, complete process mass intensity calculations, and apply the Twelve Principles of Green Chem. to compare and contrast the SNAr and B-H reactions. They finally recommend a preferred reaction procedure after considering multiple sustainability concepts in their analyses. The assignment is highly adaptable as different industry guides may be used and the SNAr reaction procedure is easily modified. Ultimately, students learn to apply sustainable chem. principles to industrially relevant reactions, an important skill for their future careers. The experimental process involved the reaction of Tris(dibenzylideneacetone)dipalladium(0)(cas: 51364-51-3Synthetic Route of C51H42O3Pd2)
Tris(dibenzylideneacetone)dipalladium(0)(cas: 51364-51-3) is used in the preparation of semiconducting polymers processed from nonchlorinated solvents into high performance thin film transistors.Synthetic Route of C51H42O3Pd2It is used as catalyst for the synthesis of epoxides, alpha-arylation of ketones, in combination with BINAP for the asymmetric heck arylation of olefins, site-selective benzylic sp3 palladium-catalyzed direct arylation and homoallylic diamination of terminal olefins.
Referemce:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI