In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 105-83-9, name is N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, introducing its new discovery. Recommanded Product: N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine
In order to determine whether there is an orientation preference of pyrrole-imidazole (Py-Im) polyamide dimers with respect to the 5′-3′ direction of the backbone in the DNA helix, equilibrium association constants (K(a)) were determined for a series of six-ring hairpin polyamides which differ with respect to substitution at the N and C termini. Affinity cleaving experiments using hairpin polyamides of core sequence composition ImPyPy-gamma-PyPyPy with an EDTA·Fe(II) moiety at the C-terminus reveal a single binding orientation at each formal match site, 5′-(A,T)G(A,T)3-3′ and 5′-(A,T)C(A,T)3-3′. A positive charge at the C-terminus and no substitution at the N-terminus imidazole affords the maximum binding orientation preference, calculated from K(a)(5′-TGTTA-3′)/K(a)(5′-TCTTA-3′), with the N-terminal end of each three-ring subunit located toward the 5′ side of the target DNA strand. Removal of the positive charge, rearrangement of the positive charge to the N-terminus or substitution at the N-terminal imidazole decreases the orientation preference. These results suggest that second generation design principles superimposed on the simple pairing rules can further optimize the sequence-specificity of Py-Im polyamides for double helical DNA.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 105-83-9 is helpful to your research. Safety of N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI