The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 119-91-5, Name is 2,2′-Biquinoline, SMILES is C1(C2=NC3=CC=CC=C3C=C2)=NC4=CC=CC=C4C=C1, in an article , author is Yasukawa, Tomohiro, once mentioned of 119-91-5, Product Details of 119-91-5.
Chiral Rhodium Nanoparticle-Catalyzed Asymmetric Arylation Reactions
The development of heterogeneous catalyst systems for enantioselective reactions is an important subject in modern chemistry as they can be easily separated from products and potentially reused; this is particularly favorable in achieving a more sustainable society. Whereas numerous homogeneous chiral small molecule catalysts have been developed to date, there are only limited examples of heterogeneous ones that maintain high activity and have a long lifetime. On the other hand, metal nanoparticle catalysts have attracted much attention in organic chemistry due to their robustness and ease of deposition on solid supports. Given these advantages, metal nanoparticles modified with chiral ligands, defined as chiral metal nanoparticles, would work efficiently in asymmetric catalysis. Although asymmetric hydrogenation catalyzed by chiral metal nanoparticles was pioneered in the late twentieth century, the application of chiral metal nanoparticle catalysis for asymmetric C-C bond-forming reactions that give a high level of enantioselectivity with wide substrate scope was very limited. This Account summarizes recent investigations that we have carried out in the field of chiral rhodium (Rh) nanoparticle catalysis for asymmetric arylation reactions. We initially utilized composites of polystyrene-based copolymers with cross-linking moieties and carbon black incarcerated Rh nanoparticle catalysts for the asymmetric 1,4-addition of arylboronic acids to enones. We found that chiral diene-modified heterogeneous Rh nanoparticles were effective in these reactions, with excellent enantioselectivities and without causing metal leaching, and that bimetallic Rh/Ag nanoparticle catalysts enhanced activity. The catalyst could be easily recovered and reused more than ten times, thus demonstrating the robustness of metal nanoparticle catalysts. We then developed a secondary amide-substituted chiral diene modifier designed as a bifunctional ligand that possesses a metal biding site and a NH group to activate a substrate through hydrogen bonding. This chiral diene was very effective for the Rh/Ag nanoparticle-catalyzed asymmetric arylation of various electron-deficient olefins, including enones, unsaturated esters, unsaturated amides and nitroolefins, and imines to afford the corresponding products in excellent yields and with outstanding enantioselectivities. The system was also applicable for the synthesis of intermediates of various useful compounds. Furthermore, the compatibility of chiral Rh nanoparticles with other catalysts was confirmed, enabling the development of tandem reaction systems and cooperative catalyst systems. The nature of the active species was investigated. Several characteristic features of the heterogeneous nanoparticle systems that were completely different from those of the corresponding homogeneous metal complex systems were found.
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Reference:
Metal catalyst and ligand design,
,Ligand Template Strategies for Catalyst Encapsulation – NCBI