Application of 3105-95-1, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 3105-95-1, Name is H-HoPro-OH, molecular formula is C6H11NO2. In a Article£¬once mentioned of 3105-95-1
L-Proline transport into renal OK epithelial cells: A second renal proline transport system is induced by amino acid deprivation
Influx of [3H]-l-proline into renal OK cells revealed that basal transport was mediated by the transporter SIT1. When cells were submitted for 8 h to amino acid deprivation, uptake of l-proline was now dominated by a low-affinity system with an apparent K m of 4.4 ¡À 0.6 mM and a V max of 10.2 ¡À 0.6 nmol/mg of protein/min operating in addition to the high-affinity SIT1 system with a K m of 0.12 ¡À 0.01 mM and a V max of 0.28 ¡À 0.04 nmol/mg of protein/min. The low- and high-affinity proline transporting systems were sensitive to inhibitors of JNK and PI-3 kinases, whereas a GSK-3 inhibitor affected only the upregulated transport system. Ion-replacement studies and experiments assessing substrate specificities for both systems provided strong evidence that SNAT2, that showed two- to threefold increased mRNA levels, is the responsible transporter mediating the increased proline influx under conditions of amino acid deprivation.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application of 3105-95-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3105-95-1, in my other articles.
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI