Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Circular dichroic studies on marmelo lactones and the related γ-lactones with unsaturation at the C-5 position.Safety of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.
The intense CD bands of marmelo lactones and the related γ-lactones with unsaturation at the C-5 position were studied in terms of the possible interactions between the n → π* transition of the carbonyl and the π → π* transition of the double bond at C-5, together with the preferred conformations about the C4-C5 axis. The C4-C5 axis of marmelo lactones takes a preferred conformation which is characteristic for the acyclic allylic alcs. and seems to be an important factor for the (4S)-γ-lactones with a double bond at the C-5 position to give a neg. coupling between the 2-chromophores.
This compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)Safety of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI