Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4411-80-7, molcular formula is C12H12N2, introducing its new discovery. HPLC of Formula: C12H12N2
Three strained Ru(II) metal-organic dyads were prepared and characterized by NMR, mass spectrometry, and analytical HPLC to probe whether these constructs could act as multifunctional photochemotherapy (PCT) agents. The compounds incorporated the crowded 6,6?-dimethyl-2,2?-bipyridine (6,6?-dmb) ligand to impart stoichiometric photocisplatin activity, and imidazo[4,5-f] [1,10]phenanthroline (IP) appended with n thiophene units (nT; n = 1-3) to add capacity for singlet oxygen sensitization. With visible light activation, each complex of the series underwent rapid and selective photoejection of 6,6?-dmb in less than 10 min, with half-lives (t1/2) as short as 46.3 s for [Ru(6,6?-dmb)2(IP-1T)]2 +. Photo-triggered ligand loss slowed with increasing n, and was slowest for [Ru(6,6?-dmb)2(IP-3T)]2 + (t1/2 = 273 s). This trend also held for photoadduct formation with DNA; [Ru(6,6?-dmb)2(IP-1T)]2 + produced relaxed circular DNA at the lowest concentrations. Singlet oxygen yields (PhiDelta) increased with n, whereby PhiDelta for [Ru(6,6?-dmb)2(IP-1T)]2 + was only 3%, but increased to 42% on going to [Ru(6,6?-dmb)2(IP-3T)]2 +. This photosensitization process was reflected by single-strand breaks in the gel-mobility shift assays of [Ru(6,6?-dmb)2(IP-3T)]2 +, but was not discernible for the other compounds. Despite different photochemical and photophysical reactivities, all of the compounds were potent phototoxic agents toward cancer cells (EC50 = 1-2 muM) with relatively short compound-to-light intervals and moderate visible light doses. [Ru(6,6?-dmb)2(IP-3T)]2 + was exceptionally photoactive toward cancer cells at longer intervals (EC50 = 200 nM, PI = 750). Phototherapeutic margins increased with n due to decreased dark cytotoxicity for the more pi-expansive complexes, making metal-organic dyad [Ru(6,6?-dmb)2(IP-3T)]2 + the best multifunctional PCT agent.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, HPLC of Formula: C12H12N2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 4411-80-7
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI