A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Computed Properties of C14H16N2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 150-61-8, Name is N1,N2-Diphenylethane-1,2-diamine, molecular formula is C14H16N2. In a Article, authors is Wnuk, Stanislaw F.£¬once mentioned of 150-61-8
Anticancer and antiviral effects and inactivation of S-adenosyl-L- homocysteine hydrolase with 5′-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues
Selectively protected adenine nucleosides were converted into 5′- carboxaldehyde analogues by Moffatt oxidation (dimethyl sulfoxide/dicyclohexylcarbodiimide/dichloroacetic acid) or with the Dess- Martin periodinane reagent. Hydrolysis of a 5′-fluoro-5′-S-methyl-5′-thio (alpha-fluoro thioether) arabinosyl derivative also gave the 5′-carboxaldehyde. Treatment of 5′-carboxaldehydes with hydroxylamine [or O-(methyl, ethyl, and benzyl)hydroxylamine] hydrochloride gave E/Z oximes. Treatment of purified oximes with aqueous trifluoroacetic acid and acetone effected trans-oximation to provide clean samples of 5′-carboxaldehydes. Adenosine (Ado)-5′- carboxaldehyde and its 4′-epimer are potent inhibitors of S-adenosyl-L- homocysteine (AdoHcy) hydrolase. They bind efficiently to the enzyme and undergo oxidation at C3′ to give 3′-keto analogues with concomitant reduction of the NAD+ cofactor to give an inactive, tightly bound NADH-enzyme complex (type I cofactor-depletion inhibition). Potent type I inhibition was observed with 5′-carboxaldehydes that contain a ribo cis-2′,3′-glycol. Their oxime derivatives are ‘proinhibitors’ that undergo enzyme-catalyzed hydrolysis to release the inhibitors at the active site. The 2′-deoxy and 2′-epimeric (arabinosyl) analogues were much weaker inhibitors, and the 3′-deoxy compounds bind very weakly. Ado-5′-carboxaldehyde oxime had potent cytotoxicity in tumor cell lines and was toxic to normal human cells. Analogues had weaker cytotoxic and antiviral potencies, and the 3′-deoxy compounds were essentially devoid of cytotoxic and antiviral activity.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 150-61-8, help many people in the next few years.Computed Properties of C14H16N2
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI