Chemistry is an experimental science, Recommanded Product: (R)-[1,1′-Binaphthalene]-2,2′-diamine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 18741-85-0, Name is (R)-[1,1′-Binaphthalene]-2,2′-diamine
Bridging 2,3 and 2?,3? positions in 2,2?-dihydroxy-1, 1?-binaphthyl and 2,2?-diamino-1,1?-binaphthyl, respectively, resulted in formation of chiral O- and N-bis-tricyclic compounds accessible in 4 steps from known 3,3?-diiodo precursors. In both cases, 2-fold ring closing metathesis of tetraallyl intermediates proceeded regioselectively to give tetrahydrobinaphtho[2,3-b]oxepine and -azepine, respectively. In case of the N-mesyl-N-allyl precursor, three, at room temperature separable, rotamers were isolated and characterized by NMR spectroscopy and X-ray structure determination. Their interconversion (process I) was followed by NMR, yielding rate constants and thermodynamic parameters. The rotamers with either C 1 or C2 symmetry were stereospecifically cyclized to conformatively moderately stable bis-sulfonamides. Also in this case, the kinetics of their interconversion (process II) was investigated and from two of them the crystal structure was determined. Processes I and II were investigated by a DFT method, M06-2X, to gain insight into electronic and steric peculiarities responsible for the remarkable conformative stabilities. Transition state geometries and energies were calculated and compared with empirical data.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: (R)-[1,1′-Binaphthalene]-2,2′-diamine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 18741-85-0, in my other articles.
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI