With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103505-54-0,[2,2′-Bipyridine]-6,6′(1H,1’H)-dione,as a common compound, the synthetic route is as follows.
Example 1 [Ru(bpy)2(66’bpy(OH)2)][PF6]2.H2O A round bottom flask containing 30 mL of 1:1 ethanol:water was degassed with argon for 30 minutes. To the flask, 0.2260 g (1.201 mmol) 66’bpy(OH)2 and 0.4843 g (0.9999 mmol) Ru(bpy)2(Cl)2 were added. The reaction mixture was heated at 80 C. under argon for 12 h. The reaction mixture turned red in color. After heating, the reaction mixture was allowed to cool to room temperature and filtered to remove any insoluble, unreacted ligand. A few drops of concentrated HCl was added to the filtrate to ensure protonation and the solution was diluted to 200 mL with water. An aqueous solution of ammonium hexafluorophosphate was added to the filtrate to precipitate the complex as the hexafluorophosphate salt. The complex was filtered and rinsed with copious amounts of water and allowed to air dry overnight. Yield: 0.5738 g (0.6309 mmol), 63%. deltaH (300 MHz, CD3CN): delta 6 8.70 (broad), delta 8.50 (d, 2H), delta 8.35 (d, 2H), delta 7.95 (m, 10H), delta 7.55 (d, 2H), delta 7.45 (t, 2H), delta 7.20 (t, 2H), delta 6.70 (d, 2H). Elem. Anal: Found: C, 39.43; N, 9.23; H, 2.89%. Calc. for RuC30N6O2H24P2F12.H2O: C, 39.62; N, 9.24; H, 2.88%.
As the paragraph descriping shows that 103505-54-0 is playing an increasingly important role.
Reference£º
Patent; The Board of Trustees of the University of Alabama; Papish, Elizabeth T.; Paul, Jared J.; Merino, Edward J.; (21 pag.)US2016/101177; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI