Let¡¯s face it, organic chemistry can seem difficult to learn, Quality Control of MitMAB, Especially from a beginner¡¯s point of view. Like 1119-97-7, Name is MitMAB, molecular formula is C6H7NO, belongs to pyridine-derivatives compound. In a document, author is Wang, Rong-Hua, introducing its new discovery.
Selective C(sp(3))-H Cleavage of Enamides for Synthesis of 2-Pyridones via Ligand-Enabled Ni-Al Bimetallic Catalysis
Previously reported direct C-H functionalization reactions of enamides mainly occurred at vinylic C(sp(2))-H bonds because of their relatively high reactivity, while less reactive beta’-C(sp(3))-H activation has been rarely explored. Herein we report a selective C(sp(3))-H cleavage of N-formyl enamides without backbone modification, providing a series of 2-pyridones in 58-99% yields. A bifunctional phosphine oxide (PO) ligand-bridging Ni-Al bimetallic catalyst played key role in the reaction.
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Reference:
Metal catalyst and ligand design,
,Ligand Template Strategies for Catalyst Encapsulation – NCBI