Simple exploration of 1245-13-2

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application of 1245-13-2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1245-13-2

Application of 1245-13-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1245-13-2, Name is [2,2′-Biquinoline]-4,4′-dicarboxylic acid, molecular formula is C20H12N2O4. In a Article£¬once mentioned of 1245-13-2

Identification of some novel AHAS inhibitors via molecular docking and virtual screening approach

Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) catalyzes the first common step in branched-chain amino acid biosynthesis. This enzyme is an important target for the design of environmental-benign herbicides. Based on the crystal structure of AHAS/sulfonylurea complex, we have carried out computational screening of the ACD-3D database in order to look for novel non-sulfonylurea inhibitors of AHAS for the first time. Three novel compounds were found to inhibit plant AHAS in vitro among 14 procured compounds. One compound showed promising activity in vivo for rape root growth inhibition bioassay. This research provided useful clues for further design and discovery of AHAS inhibitors.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application of 1245-13-2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1245-13-2

Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI