With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1970-80-5,(2,2-Bipyridine)-5-carboxylic acid,as a common compound, the synthetic route is as follows.
Compound 7 (600 mg, 0.56 mmol) was suspended in methylene chloride (15 ml), and compound 11 (0.5 g, 2.5 mmol),Triethylamine (0.6 ml, 4.33 mmol), DMAP (0.1 ml) was added. The solution was cooled with ice,WSC (1.7 g, 8.9 mmol) was added and the mixture was stirred for 24 hours. The solvent was concentrated to dryness and the crude product was purified by silica gel column chromatography to obtain 0.5 g (yield 36%) of TPE-Bipy.
As the paragraph descriping shows that 1970-80-5 is playing an increasingly important role.
Reference£º
Patent; DOJINDO LABORATORIES; SHINKAI, SEIJI; SHIGA, MASANOBU; OSETO, FUMIO; NOGUCHI, TAKAO; (18 pag.)JP6081152; (2017); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI