With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2304-30-5,Tetrabutylphosphonium chloride,as a common compound, the synthetic route is as follows.
EXAMPLE 1 Preparation of 2,4,6-tris(o-aminophenylthiomethyl)mesitylene A 2-liter glass reaction vessel equipped with a Teflon stirrer, reflux condenser, addition funnel, 2-thermometers and an electrical heater was charged with 243 g water and 104.2 g sodium hydroxide pellets. After boiling under a nitrogen atmosphere for 5 minutes, 167.8 g benzothiazole was gradually added to the contents of the reactor over 50 minutes. The resultant mixture was then heated at the boiling point for 2 hours. A solution of 0.5 g tetrabutyl phosphonium chloride (50% in toluene) and 50 g toluene was then added, which cooled the reaction mixture to 90 C. A solution of 100 g 2,4,6-tris(chloromethyl)mesitylene in 300 g of warm toluene was added over a 15 minute period and the resultant mixture was heated at the boiling point for 2 hours. The aqueous phase of the reaction mixture was then removed and the organic phase washed with 100 g hot water. The residual water was removed by azeotropic distillation. After being filtered the toluene solution gradually cooled to room temperature, during which time a slightly off-white solid crystallized. The solid was filtered off, washed sequentially with cold toluene and heptane and then dried under reduced pressure at 90 C. The product weighed 164.7 g melted from 161 to 166 C. and exhibited an amine equivalent of 181. The theoretical amine equivalent for the expected product, 1,3,5-tris(o-aminophenylthiomethyl)mesitylene is 178.
2304-30-5, As the paragraph descriping shows that 2304-30-5 is playing an increasingly important role.
Reference£º
Patent; M&T Chemicals Inc.; US4187250; (1980); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI