With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3779-42-8,3-Bromo-N,N,N-trimethylpropan-1-aminium bromide,as a common compound, the synthetic route is as follows.
Compound 45 (50 mg, 0.062 mmol) and (3-bromopropyl)- trimethylammonium bromide (162mg, 0.62 mmol, LOEQV.) are dissolved and potassium carbonate (128 mg, 0.93 mmol, 15 eqv. ) is suspended under argon in absolute DMF (30 ML) and the mixture is stirred at 55C for 12 h. The solvent is removed in vacuo at 50C and the residue re- dissolved in a little methanol and applied to a pad of silica (2 cm deep). The unreacted ammonium salts are washed off with methanol (LOOOML). The product is eluted with acetic acid: methanol: water (3: 2: 1 by vol.). The solvents are removed under reduced pressure and the product further purified by chromatography on a column (lOOg) of Sephadex LH-20 eluting with n-butanol: water: acetic acid (4: 5: 1 by vol. , upper phase). The solvents are removed under reduced pressure, the residue re-dissolved in a little methanol and the solution is passed through a short column of anion exchange resin (Amberlite IRC 400, chloride form) using methanol as eluent. After removal of solvent, the product is dried at high vacuum to give a violet solid. 1H-NMR : 6H (300MHZ, CD30D) : 0. 89 (t, 3H, 3J= 7.5 Hz), 1.18-1. 34 (m, LOH), 1.41 (bs, 2H), 1.73 (quint, 2H, 3J= 7.5 Hz), 2.30-2. 44 (m, 6H), 3,31 (bs, 27H), 3.65-3. 73 (m, 6H), 3.93 (t, 2H, 3J= 7.5 Hz), 4.25-4. 42 (m, 6H), 7.08 (d, 2H, 3J= 7.5 Hz), 7. 30 (d, 6H, 3J= 7.5 Hz), 7.93 (d, 2H, 3J= 7.5 Hz), 8.05 (d, 6H, 3J= 7.5 Hz), 8.94 (bs, 8H)
3779-42-8, The synthetic route of 3779-42-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; DESTINY PHARMA LIMITED; SOLVIAS AG; WO2004/56828; (2004); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI