A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of N1,N2-Di-tert-butylethane-1,2-diamine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4062-60-6, Name is N1,N2-Di-tert-butylethane-1,2-diamine, molecular formula is C10H24N2. In a Article, authors is Patel, Dushyant V.£¬once mentioned of 4062-60-6
Novel carbazole-stilbene hybrids as multifunctional anti-Alzheimer agents
Molecules capable of engaging with multiple targets associated with pathological condition of Alzheimer’s disease have proved to be potential anti-Alzheimer’s agents. In our goal to develop multitarget-directed ligands for the treatment of Alzheimer’s disease, a novel series of carbazole-based stilbene derivatives were designed by the fusion of carbazole ring with stilbene scaffold. The designed compounds were synthesized and evaluated for their anti-AD activities including cholinesterase inhibition, Abeta aggregation inhibition, antioxidant and metal chelation properties. Amongst them, (E)-1-(4-(2-(9-ethyl-9H-carbazol-3-yl)vinyl)phenyl)-3-(2-(pyrrolidin-1-yl)ethyl)thiourea (50) appeared to be the best candidate with good inhibitory activities against AChE (IC50 value of 2.64 muM) and BuChE (IC50 value of 1.29 muM), and significant inhibition of self-mediated Abeta1?42 aggregation (51.29% at 25 muM concentration). The metal chelation study showed that compound (50) possessed specific copper ion chelating property. Additionally, compound (50) exhibited moderate antioxidant activity. To understand the binding mode of 50, molecular docking studies were performed, and the results indicated strong non-covalent interactions of 50 with the enzymes in the active sites of AChE, BuChE as well as of the Abeta1-42 peptide. Additionally, it showed promising in silico ADMET properties. Putting together, these findings evidently showed compound (50) as a potential multitarget-directed ligand in the course of developing novel anti-AD drugs.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4062-60-6, help many people in the next few years.Application In Synthesis of N1,N2-Di-tert-butylethane-1,2-diamine
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI