With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4479-74-7,2,2-Bipyridine-6,6-dicarboxylic Acid,as a common compound, the synthetic route is as follows.
General procedure: A mixture of 2,2?-bipyridine-6,6?-dicarboxylic acid (244 mg,1.0 mmol), Ru(DMSO)4Cl2 (484 mg, 1.0 mmol), and Et3N (0.8ml) in methanol (10 ml) was degassed with N2 and refluxed for 4 h. The solution changed from bright yellow to dark before the appearance of a brown precipitate. After cooling to room temperature, the precipitate was filtered and washed with methanol (10 ml ¡Á 3) and ether (10 ml ¡Á 3) to get a reddish-brown powder. The powder was mixed with an excess of 4,4?-bipyridine in methanol (20 ml) and heated to reflux for 2 h. The solvent was removed and the resulted residue was re-dissolved in dichloromethane, washed with water to remove triethylamine hydrochloride, and dried over MgSO4 under N2. After purification by column chromatography on silica gel with dichloromethane-methanol (20:1 to 1:1, V:V) as eluent, complex1 was obtained as a dark red solid. Yield: 229 mg (35%)., 4479-74-7
The synthetic route of 4479-74-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Jiang, Yi; Li, Fei; Huang, Fang; Zhang, Biaobiao; Sun, Licheng; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 34; 8; (2013); p. 1489 – 1495;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI