With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.,4730-54-5
20 g of triazacyclononane trihydrochloride (83.8 mmol), 35.4 g of 1-fluoro-4-nitrobenzene (251.4 mmol) and 40 g of potassium carbonate (290 mmol) are placed in 150 ml of water and the mixture is refluxed with stirring for 24 hours. After cooling to room temperature, the orange-yellow solid obtained is filtered off and rinsed with water and then with petroleum ether. After drying, 31 g of product are obtained, i.e. a yield of 99%. The results of the analyses obtained by 1H NMR and by mass spectrometry are as follows: 1H NMR (400 MHz, DMSO): 2.2 (m, 1H); 2.8 (m, 4H); 3.4 (m, 4H); 3.9 (m, 4H); 6.8 (m, 4H); 8.1 (m, 4H). Mass (ESI+): m/z=372 (MH+).
The synthetic route of 4730-54-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Vidal, Laurent; Sabelle, Stephane; Ly-Carry, Thi-My; US2005/120494; (2005); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI