With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54258-41-2,1,10-Phenanthrolin-5-amine,as a common compound, the synthetic route is as follows.
General procedure: Amine 2 (1.0 mmol), 2,5-dimethoxytetrahydrofuran (1, 1.2 mmol) and bismuth nitrate pentahydrate (24 mg, 5 mol%) was irradiated in a B5510-DTH (Branson ultrasonic cleaner; Model-5510, frequency 42 kHz with an output power 135 Watts), as specified in Table 2. After completion of the reaction (monitored by TLC) diethyl ether (10 mL) was added to the reaction mixture and filtered. Pure product was isolated from the reaction mixture after evaporation of ether.
The synthetic route of 54258-41-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Bandyopadhyay, Debasish; Mukherjee, Sanghamitra; Granados, Jose C.; Short, John D.; Banik, Bimal K.; European Journal of Medicinal Chemistry; vol. 50; (2012); p. 209 – 215;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI