With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54761-04-5,Ytterbium(III) trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.
Under the protection of nitrogen atmosphere, the amount of organic solvent (for the volume ratio of 1: 0.2 of a mixture of polyethylene glycol and 15-crown-5) was added 100 mmol of the compound of formula (I) 250 mmol of the compound of formula (II) above, 9 mmol of catalyst (3 mmol Pd(dba)2) With 6mmol A mixture of ytterbium trifluoromethanesulfonate ,12 mmol oxidizer silver acetate and 30 mmol accelerator N-n-butyl-N-methylpiperidine bis(trifluoromethanesulfonyl)imide salt, and then the temperature was raised to 70 C, and the reaction was stirred at that temperature for 6 hours. After the reaction is complete, the filtrate is adjusted to adjust the pH of the filtrate to neutral and then saturated with hydrogen carbonate Sodium aqueous solution is fully shaken washing, adding dichloromethane extraction, separation of organic phase, and then Dried over anhydrous sodium sulfate, concentrated under reduced pressure, the residue over 200-300 mesh silica gel column chromatography, in vivo A mixture of petroleum ether and acetone having a ratio of 1: 3 was used as the eluent to give a compound of formula (III) And the yield was 93.9%., 54761-04-5
The synthetic route of 54761-04-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Henan Academy Of Sciences Chemical Institute Co., Ltd.; Huo Cuimeng; Fu Yang; Chen Jin; Zhang Xin; Zhao Yongde; (9 pag.)CN105037081; (2016); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI