With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.554-95-0,Benzene-1,3,5-tricarboxylic acid,as a common compound, the synthetic route is as follows.
20.00 g of trimesic acid was dissolved in 350 mL of methanol, 5 mL of 18 mol / L concentrated sulfuric acid catalyst was added slowly and refluxed at 73 oC for 24 h.The solvent was evaporated under reduced pressure, 60 mL of chloroform was added until just dissolved, and 130 mL of a 100 g / L saturated sodium bicarbonate solution was added until the pH was neutral.The organic phase was separated and the solvent was evaporated under reduced pressure and dried under vacuum at 80 C to give 23.03 gTrimellitic acid methyl ester(96% yield).
The synthetic route of 554-95-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Jilin Chemical College; Gao Wenxiu; Wang Jisi; Lou Dawei; Yu Dandan; Zhang Zhihui; Zhang Hao; (9 pag.)CN107501043; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI