Simple exploration of 6-Bromo-2,2′-bipyridine

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Electric Literature of 10495-73-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.10495-73-5, Name is 6-Bromo-2,2′-bipyridine, molecular formula is C10H7BrN2. In a Article，once mentioned of 10495-73-5

Cyclometalating ligands 6-(1-phenylethyl)-2,2?-bipyridine (L4), 6-(1-phenylvinyl)-2,2?-bipyridine (L5), and 6-(prop-1-en-2-yl)-2,2?-bipyridine (L6) were synthesized by the Negishi coupling of 6-bromo-2,2?-bipyridine with the corresponding organozinc reagents. The reaction of L4 with K2PtCl4 produced only the cycloplatinated compound 4a via sp2 C-H bond activation. The reactions of L5 and L6 produced exclusively the cycloplatinated compounds 5b and 6a, respectively, via vinylic C-H bond activation. DFT calculations were performed on 12 possible cycloplatination products from the reaction of N-alkyl-N-phenyl-2,2?-bipyridin-6-amine (alkyl = methyl (L1), ethyl (L2), and isopropyl (L3)) and L4-L6. The results show that compounds 1b-3b resulting from the sp3 C-H bond activation of L1-L3 are thermodynamic products, and their relative stability is attributed to the planar geometry that allows for a better conjugation. Similar reasoning also applies to the stability of products from vinylic C-H bond activation of L5 and L6. The relative stability of isomeric cycloplatinated compounds 4a and 4b may be due to the different strengths of C-Pt bonds. The steric interaction is the major cause of severe distortion from a planar coordination geometry in the cycloplatinated compounds, which leads to instability of the corresponding cyclometalated products and a higher kinetic barrier for C-H bond activation.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI