With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7089-68-1,2-Chloro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.,7089-68-1
In the atmosphere of nitrogen, intermediate A2 (1.6g, 5.6 mmol), 2-chlorophenanthroline (0.8g, 3.7 mmol), tetrakis(triphenylphosphine)palladium (0) (0.1g, 0.11 mmol), cesium carbonate (3.0g, 9.3 mmol) and 1,2-dimethoxyethane (37 mL) were mixed, followed by stirring at 80¡ãC for 6 hours. Water (50 mL) was added to the reaction mixture, and the precipitates were filtered out to obtain a yellow solid (compound (2-A); 0.76g, 60percent).1H-NMR (400MHz, CDCl3, TMS)delta: 3.25 (s,3H), 7.70 (d,J8.0,1H), 8.03 (d,J8.0,1H), 8.18 (d,J8.0,1H), 8.30 (d,J8.0,1 H), 8.41 (d,J8.0,1H), 8.69 (s,1H), 8.83 (d,J8.0,1 H), 9.26 (d,J8.0,1H).
The synthetic route of 7089-68-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Idemitsu Kosan Co., Ltd.; YASUKAWA, Keiichi; MAEDA, Ryoji; TOKAILIN, Hiroshi; EP2599780; (2013); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI