With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7173-51-5,N-Decyl-N,N-dimethyldecan-1-aminium chloride,as a common compound, the synthetic route is as follows.,7173-51-5
In a round-bottom flask, equipped with a magnetic stirrer, heating bath, dropping funnel, and a reflux condenser, a suspension of 0.02 mol of 3,6-dichloro-2- methoxybenzoic acid in 30 mL of distilled water, was prepared. Then 0.02 mol of 10% aqueous solution of NaOH was added to the suspension. The reaction was conducted at 50C until the all acid reacted and a homogeneous reaction mixture was obtained. Then a stoichiometric amount of didecyldimethylammonium chloride was added in a 1 to 1 (50%: 50%) water and isopropanol mixture. The product precipitated from the reaction mixture in the form of a lower liquid layer. After 24 hours, the product was isolated by separating the phases. The organic phase was washed with distilled water from the unreacted substrate and the NaCl. In the final stage the product was dried for 24 hours at 50C under reduced pressure. The yield is 90%. 1H NMR (CDC13) delta ppm = 0.88 (t, J= 6.7 Hz, 6H), 1.25 (m, 28H), 1.61 (q, J = 6.8 Hz, 4H), 3.34 (s, 6H), 3.39 (t, J= 6.3 Hz, 4H), 3.95 (s, 3H), 6.99 (d, J= 8.5 Hz, 1H), 7.08 (d, J= 8.5 Hz, 1H); 13C NMR delta ppm = 14.0; 22.5; 26.1; 29.1; 29.25; 29.27; 31.7; 50.9; 61.5; 63.1; 125.3; 125.9; 127.0; 127.8; 140.2; 151.7; 167.9. Elemental analysis CHN CsoHssOsNCb: calculated C 65.90; H 9.79; N 2.56; observed: C 65.62; H 9.65; N 2.33. DSC: T glass -47C, mp 86C, T = 178C; 1 onset 232C
The synthetic route of 7173-51-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA; PERNAK, Juliusz; SHAMSHINA, Julia; TADEUSZ, Praczyk; SYGUDA, Anna; JANISZEWSKA, Dominika; SMIGLAK, Marcin; GURAU, Gabriela; DALY, Daniel, T.; ROGERS, Robin, D.; WO2012/6313; (2012); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI