Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 117408-98-7, molcular formula is C12H16N2O, introducing its new discovery. Quality Control of: (S)-4-tert-Butyl-2-(2-pyridyl)oxazoline
We have developed a nickel-catalyzed method for the asymmetric cross-coupling of secondary electrophiles with secondary nucleophiles, specifically, stereoconvergent Negishi reactions of racemic benzylic bromides with achiral cycloalkylzinc reagents. In contrast to most previous studies of enantioselective Negishi cross-couplings, tridentate pybox ligands are ineffective in this process; however, a new, readily available bidentate isoquinoline-oxazoline ligand furnishes excellent ee’s and good yields. The use of acyclic alkylzinc reagents as coupling partners led to the discovery of a highly unusual isomerization that generates a significant quantity of a branched cross-coupling product from an unbranched nucleophile.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Quality Control of: (S)-4-tert-Butyl-2-(2-pyridyl)oxazoline, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 117408-98-7
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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI