Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1660-93-1, molcular formula is C16H16N2, introducing its new discovery. Computed Properties of C16H16N2
Synthesis, isomerisation and biological properties of mononuclear ruthenium complexes containing the bis[4(4?-methyl-2,2?-bipyridyl)]-1,7-heptane ligand
A series of mononuclear ruthenium(ii) complexes containing the tetradentate ligand bis[4(4?-methyl-2,2?-bipyridyl)]-1,7-heptane have been synthesised and their biological properties examined. In the synthesis of the [Ru(phen?)(bb7)]2+ complexes (where phen? = 1,10-phenanthroline and its 5-nitro-, 4,7-dimethyl- and 3,4,7,8-tetramethyl- derivatives), both the symmetric cis-alpha and non-symmetric cis-beta isomers were formed. However, upon standing for a number of days (or more quickly under harsh conditions) the cis-beta isomer converted to the more thermodynamically stable cis-alpha isomer. The minimum inhibitory concentrations (MIC) and the minimum bactericidal concentrations (MBC) of the ruthenium(ii) complexes were determined against six strains of bacteria: Gram-positive Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA); and the Gram-negative Escherichia coli (E. coli) strains MG1655, APEC, UPEC and Pseudomonas aeruginosa (P. aeruginosa). The results showed that the [Ru(5-NO2phen)(bb7)]2+ complex had little or no activity against any of the bacterial strains. By contrast, for the other cis-alpha-[Ru(phen?)(bb7)]2+ complexes, the antimicrobial activity increased with the degree of methylation. In particular, the cis-alpha-[Ru(Me4phen)(bb7)]2+ complex showed excellent and uniform MIC activity against all bacteria. By contrast, the MBC values for the cis-alpha-[Ru(Me4phen)(bb7)]2+ complex varied considerably across the bacteria and even within S. aureus and E. coli strains. In order to gain an understanding of the relative antimicrobial activities, the DNA-binding affinity, cellular accumulation and water-octanol partition coefficients (logP) of the ruthenium complexes were determined. Interestingly, all the [Ru(phen?)(bb7)]2+ complexes exhibited stronger DNA binding affinity (Ka ? 1 ¡Á 107 M-1) than the well-known DNA-intercalating complex [Ru(phen)2(dppz)]2+ (where dppz = dipyrido[3,2-a:2?,3?-c]phenazine).
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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI