Chemistry is an experimental science, Formula: C14H16N2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 29841-69-8, Name is (1S,2S)-(-)-1,2-Diphenylethylenediamine
The catalytic enantioselective Mannich-type reaction between glycinate Schiff base and imines has been one of the most efficient routes for accessing alpha,beta-diamino acids. However, the glycinate Schiff bases used in the references were almost ketimines. Only several examples of aldimines were used in the presence of metal catalyst. We developed the first example of an asymmetric direct Mannich reaction using aldimines of glycinates instead of ketimines of glycinates. The reaction was well catalyzed by chiral guanidine with high yield (up to 92%) and moderate stereoselectivity (up to 65%).
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application In Synthesis of (1S,2S)-(-)-1,2-Diphenylethylenediamine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 29841-69-8, in my other articles.
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI