115754-62-6, ((1,3-Dioxolan-2-yl)methyl)tributylphosphonium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,115754-62-6
General procedure: The compounds 4ab were synthesized via modified literature procedure [34]. Aldehyde 3a or 3b (2 mmol) and tributyl(1,3- dioxolan-2-ylmethyl)phosphonium bromide (1.63 g, 4.4 mmol) were dissolved in dry THF (50 mL). Argon was bubbled through the solution for 15 min, NaH (144 mg, 6 mmol) was added and the reaction mixture was stirred at room temperature for 24 h. The reaction mixture was diluted with water (100 mL) and extracted with EtOAc (3 100 mL). The combined organic layers were dried (Na2SO4) and the solvents were evaporated in vacuo. The residue was dissolved in THF (100 mL), 12% HCl (50 mL) was added and the solution was stirred for 1 h. The reaction mixture was diluted with water (100 mL) and extracted with EtOAc (3 100 mL). Both products 4a and 4b are sparingly soluble in common organic solvents. Therefore, the collected organic suspensions was concentrated in vacuo and precipitate was filtered off. The crude product 4a or 4b was suspended in EtOAc (50 mL), the suspension was refluxed for 30 min, cooled to 25 C and the product was isolated by filtration. After drying, products 4a and 4b were used in the following reaction step without further purification. A full purification of small quantities is possible by column chromatography (SiO2, CH2Cl2/EtOAc 10:1) using large excess of the eluting solvents.
115754-62-6 ((1,3-Dioxolan-2-yl)methyl)tributylphosphonium bromide 22292430, acatalyst-ligand compound, is more and more widely used in various fields.
Reference£º
Article; Speratova, Michaela; Jedyrka, Jaroslaw; Pytela, Old?ich; Kityk, Iwan V.; Reshak; Bure?; Klikar; Tetrahedron; vol. 75; 34; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI