With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.153-94-6,H-D-Trp-OH,as a common compound, the synthetic route is as follows.
Example 1 To a 1L three-necked flask was added 200mL of tetrahydrofuran, 20g D-tryptophan, 7.7g methylaminoacetonitrile, 38.2g EDC ¡¤ HCl and 1g 4-dimethylaminopyridine. The reaction was stirred at room temperature for 5 hours. After completion of the reaction, 300mL of ethyl acetate and 300mL water was added. The ethyl acetate layer was washed with 200mL saturated sodium chloride and stirred. Still stratification of the ethyl acetate layer was distilled under reduced pressure at 30C to a volume of about 200ml. The solution was recrystallized with 700ml of petroleum ether, filtered and vacuum dried at 40C to give 22.25g of compound III. HPLC purity 98%, Yield 91%., 153-94-6
153-94-6 H-D-Trp-OH 9060, acatalyst-ligand compound, is more and more widely used in various fields.
Reference£º
Patent; Zhejiang Yongning Pharmaceutical Co., Ltd.; Ye, Tianjian; Yuan, Youting; Chen, Xin; Zhang, Hongxun; (7 pag.)CN105348283; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI