With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.
5mmol of Phen-NH2, 5.5mmol of indoline-2,3-dione and 0.1mmol of 4-methylbenzenesulfonic acid were added into 25mL of ethanol and heated to reflux overnight. After cooling, the solution was poured into 300mL of cold water. The crude product was collected and recrystalized in ethanol to yield IPP as gray powder. 1H NMR (300Hz, CDCl3, 25¡ãC): delta 10.13 (d, 1H, J=8.5Hz), 9.24 (d,1H, J=2.5Hz), 9.17 (d, 1H, J=2.0Hz), 9.09 (d, 1H, J=5.5Hz), 8.55 (d, 1H, J=5.5Hz), 7.60?7.64 (m, 2H), 7.55 (d, 1H, J=8.5Hz), 7.34 (m, 2H). Anal. Calcd for C20H11N5: C, 74.76; H, 3.45; N, 21.79. Found: C, 74.67, H, 3.60; N, 21.68., 168646-54-6
As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.
Reference£º
Article; Li, Xiaogang; Zhang, Dong; Li, Jing; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 127; (2014); p. 1 – 9;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI