With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170161-27-0,Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate,as a common compound, the synthetic route is as follows.
A mixture of terephthalaldehyde (134 mg, 1.0 mmol) and triBoc-cyclam (250 mg, 500 mol) inDCM (10 mL) was stirred at ambient temperature for 2 h and then sodium triacetoxyborohydride (318mg, 1.5 mmol) was added. The mixture was stirred overnight at ambient temperature. The reaction wasquenched with aqueous NaHCO3, the layers were separated and the aqueous layer was extracted withdichloromethane. The combined organic layers were dried over anhydrous sodium sulfate andevaporated. The crude residue was purified by Combi-Flash (silica gel; ethyl acetate in hexanes) to givePKS8204 (198 mg, 64%) as a colorless gum, which turned into a fluffy solid under vacuum., 170161-27-0
As the paragraph descriping shows that 170161-27-0 is playing an increasingly important role.
Reference£º
Article; Amor-Coarasa, Alejandro; Kelly, James M.; Singh, Pradeep K.; Ponnala, Shashikanth; Nikolopoulou, Anastasia; Williams, Clarence; Vedvyas, Yogindra; Jin, Moonsoo M.; David Warren; Babich, John W.; Molecules; vol. 24; 8; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI