56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A solution of quinine/quinidine 5 in dry DMF (4 mL/mmol 5) was treated with dry NaH (2.8 equiv.) and the resulting mixture was stirred at r.t. for 2 h. Benzyl chloride or allyl bromide (1.1 equiv.) were added and the resulting mixture was stirred at r.t. for 20 h. After extraction with brine and EtOAc the organic phase was dried over Na2SO4, filtrated and evaporated to dryness, giving 9-O-allylated or 9-O-benzylated compounds 6 [26] in >87% yield and sufficient purity for the following steps.
The synthetic route of 56-54-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Schoergenhumer, Johannes; Otte, Stefan; Haider, Victoria; Novacek, Johanna; Waser, Mario; Tetrahedron; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI