62937-45-5,62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of N((5-(5-(difluoromethyl)- 1,3 ,4-oxadiazol-2-yl)pyridin-2-yl)methyl)-N-phenylethenesulfonamide (0.100 g, 0.255 mmol), D-(-)-Prolinamide (0.058 g, 0.5 10 mmol) and Diisopropylethylamine (0.176 mL, 1.019 mmol) in dichioromethane (5 mL) was stirred at the room temperature for 24 hr. Then, water was added to the reaction mixture, followed by extraction with dichloromethane. The organic layer was washed with aqueous saturated sodium chloride solution, dried with anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was chromatographed (Si02, 12 g cartridge; methanol / dichloromethane = 5 % to 10 %) to give(R)- 1 -(2-(N-((5-(5-(difluoromethyl)- 1,3 ,4-oxadiazol-2-yl)pyridin-2-yl)methyl)-N-phen ylsulfamoyl)ethyl)pyrrolidine-2-carboxamide as white solid (0.045 g, 34.9 %).?H NMR(400 MHz, CD3OD): oe 9.17 (dd, 1 H, J= 2.2, 0.8 Hz), 8.43 (dd, 1 H, J=8.3, 2.3 Hz), 7.76 (dd, 1 H, J = 8.2, 0.8 Hz), 7.55 – 7.44 (m, 2 H), 7.46 – 7.35 (m, 1 H),7.40 – 7.19 (m, 3 H), 5.17 (s, 2 H), 3.63 – 3.46 (m, 2 H), 3.32 – 2.76 (m, 3 H), 2.65 (q, 1H, J= 7.3 Hz), 2.45 -2.28 (m, 1 H), 2.30-2.12 (m, 1 H), 1.92- 1.71 (m, 3 H); LRMS(ES) mlz 507.3 (M¡Â+1).
The synthetic route of 62937-45-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; HAN, Younghue; KIM, Yuntae; CHOI, Daekyu; MIN, Jaeki; BAE, Miseon; YANG, Hyunmo; KIM, Dohoon; (644 pag.)WO2017/18803; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI