62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
62937-45-5, Example 53(fi)-1 -[5-(4-{(S)-1 -[(S)-6-(2-Hvdroxy-2-methyl-DroDyl)-2-oxo-6-Dhenyl-[1 .3loxazinan-3-yll- ethyl)-phenyl)-pyridin-2-yl1-pyrrolidine-2-carboxylic acid amide; A mixture of 3-{(S)-1 -[4-(6-fluoro-pyridin-3-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl- propyl)-6-phenyl-[1 ,3]oxazinan-2-one (165 mg), potassium carbonate (76 mg), D-prolinamide (125 mg), and dimethyl sulfoxide (2 ml_) was stirred at 100 ‘ overnight. After cooling to room temperature, aqueous NaHC03 solution was added and the resulting mixture was extracted with dichloromethane. The combined extracts were concentrated and the residue was purified by HPLC on reversed phase (water/methanol) to give the title compound. Yield: 85 mg (43% of theory); Mass spectrum (ESI+): m/z = 543 [M+H]+.
The synthetic route of 62937-45-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LEFTHERIS, Katerina; ZHUANG, Linghang; TICE, Colin, M.; SINGH, Suresh, B.; YE, Yuanjie; XU, Zhenrong; HIMMELSBACH, Frank; ECKHARDT, Matthias; WO2011/159760; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI