6813-38-3, [2,2′-Bipyridine]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
6813-38-3, A monocarboxylic acid, 4-carboxy-4?-ethyl-2,2?-bipyridine 9 was identified as methyl ester as follows. Isolated mixture of 2 and 9 (Table 4, entry 5) was dissolved in 40 mL methanol, and 1 mL conc. H 2 SO 4 was added. The solution was refluxed for 24h, and then the cooled mixture was neutralized by adding aqueous NaHCO 3 solution. After removal of methanol at reduced pressure, H 2 O was added to the residue, and insoluble dimethyl 2,2′-bipyridine-4,4′-dicarboxylate S7 was filtered off and washed well with H 2 O. The filtrate and washings were combined and extracted with CH 2 Cl 2 . The organic layer was separated, dried with anhydrous Na 2 SO 4 , and the solvent was removed out under a reduced pressure. The colorless oil obtained was identified as 4-ethyl-4?-methoxycarbonyl-2,2?-bipyridine 16by its spectral data. The colorless oil solidified on standing several days in freezer. 4-Ethyl-4?-methoxycarbonyl-2,2?-bipyridine 16: mp 38-40C 1 H NMR (400 MHz, CDCl 3 ,TMS) ppm: 1.32 (3H, t, J=7.6 Hz), 2.76 (2H, q, J=7.6 Hz), 7.20 (1H, dd, J=5.0 Hz, 1.8 Hz), 7.86 (1H, dd, J=5.0 Hz, 1.8 Hz) 8.28 (1H, t, J=0.9 Hz), 8.61 (1H, d, J=5.0 Hz), 8.63 (2H, s), 8.82 (1H, dd, J=5.0 Hz, 0.9 Hz) 8.93 (1H, t, J=0.9 Hz); 13 C NMR (100 MHz, CDCl 3 , TMS) ppm: 14.4, 28.4, 52.7, 120.6, 120.9, 122.7, 123.9, 138.5, 149.3, 149.8, 154.2, 155.2, 157.5, 165.8. IR (ATR, cm -1 ) 3437, 3056, 2967, 2947, 2925, 2882, 2847, 1932, 1721, 1592, 1552, 1460, 1439, 1291, 1230, 1106, 963, 843, 747, 684; MS (EI) m/z(%) 242 (79) [M] + , 241 (96), 184 (100); Anal. Calcd for C 14 H 14 N 2 O 2 : C, 69.41; H, 5.82; N, 11.56. Found: C, 69.31; H, 6.00; N, 11.16.
The synthetic route of 6813-38-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Yamazaki, Shigekazu; Synthetic Communications; vol. 49; 17; (2019); p. 2210 – 2218;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI