99970-84-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99970-84-0,[2,2′-Bipyridine]-4,4′-dicarbaldehyde,as a common compound, the synthetic route is as follows.
{RuCl(p-cymene)}2(50 mg, 0.08 mmol) and DiPy-G1-MEH (276 mg, 0.16 mmol) were dissolved in distilled DMF (25 mL). The reaction mixture was heated at 80 C. under nitrogen for 4 hours. Then, 2,2′-bipyridine-4,4′-dicarboxaldehyde (Dcbpy) (40 mg, 0.16 mmol) was added and refluxed at 150-160 degrees C. for another 4 hours under reduced light to avoid isomerization (2,2′-bipyridine-4,4′-dicarboxaldehyde was prepared according to the method described in N. Garelli et al, J. Org. Chem. 1992, 57, 3046). Subsequently, an excess of NH4NCS (310 mg, 4.1 mmol) was added to the mixture and heated at 150 C. for a further 4 h. The reaction mixture was cooled to room temperature and the solvent was removed by using a raotary evaporator under vacuum. Water (20 mL) was added to the flask and the insoluble solid was collected on a sintered glass crucible by suction filtration, and washed with distilled water. The crude complex was dissolved on a solution of tetrabutylammonium hydroxide (TBAH) in methanol (5 mL). the concentrated solution was charged onto a Sephadex LH-20 column and eluted with methanol. The main band was collected and concentrated. The required complex was isolated upon addition of 0.01M HNO3.
As the paragraph descriping shows that 99970-84-0 is playing an increasingly important role.
Reference£º
Patent; Isis Innovation Limited; Burn, Paul Leslie; An, Byeong-Kwan; Meredith, Paul; Deceglie, Michael Gardner; US8598350; (2013); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI