SDS of cas: 2834-05-1. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Cysteine Derivatized 99mTc-Labelled Fatty Acids as β-Oxidation Markers. Author is Tsotakos, Theodoros; Triantis, Charalambos; Kiritsis, Christos; Panagiotopoulou, Aggeliki; Psimadas, Dimitrios; Kyprianou, Patricia; Pelecanou, Maria; Papadopoulos, Minas; Pirmettis, Ioannis.
With the aim of developing 99mTc-labeled fatty acids intended for myocardial metabolism imaging we report herein the synthesis and characterization of two novel derivatives of undecanonoic and hexadecanonoic acid that have been functionalized at the ω-site by cysteine through the formation of a thioether bond (Cys-FA11 and Cys-FA16). Equimolar amounts of each ligand and the [NEt4]2[Re(CO)3Br3] precursor generated the resp. hexacoordinated neutral complexes in which the ligand coordinated to the metal through the SNO donor system of cysteine. The rhenium complexes were characterized by elemental anal., IR and NMR spectroscopies. The analogus technetium-99m complexes, 99mTc-Cys-FA11 and 99mTc-Cys-FA16 were prepared by incubation of the ligand with the precursor [99mTc(CO)3(H2O)3]+ (radiochem. yield ≥98%). Their structure was established by comparative HPLC techniques. In vivo studies in mice showed high initial heart uptake for both 99mTc complexes (7.4 ±plusmn; 0.53 and 7.07 &± 0.73 percentage of injected dose (%ID)/g at 1 min post) injection. Rapid clearance (0.60 ± 0.02%ID/g) was observed for 99mTc-Cys-FA11 while the clearance of the longer fatty acid 99mTc-Cys-FA16 was slower (2.31 ±0.09%ID/g at 15 min p.i.). Metabolite anal. study indicated that complexes were catabolized through the β-oxidation process.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI