Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 32780-06-6, is researched, Molecular C5H8O3, about Calculations of Cotton effects in the vacuum UV region for chiral γ-lactones: correlation with the absolute stereochemistry, the main research direction is Cotton effect lactone absolute configuration; configuration absolute lactone Cotton effect; CD lactone; ORD lactone.Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.
A graphic method of Drude equations was applied to calculate the Cotton effects below 180 nm region for various types of α- and/or γ-substituted γ-lactones, e.g., I (R1 = H, NH2, NH3Cl; R2 = H, OH; R3 = H, Me) and II (R = H, Br, etc.). The Cotton effects at ∼170 nm were found to reflect the stereochem. at C-2 (neg. for β and pos. for α) and C-4 (pos. for β and neg. for α) as well as the ring conformation (pos. for E3 and neg. for 3E). The rotational contributions at 589 nm were suggested to be the origin of Hudson’s lactone rule.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI