Tag: 103946-54-9

103946-54-9, 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 10; Synthesis of dye; 57 mg of a product was obtained in the same manner as the “synthesis of dye” in Example 5 except that 34.28 mg of 4-carboxy-4′-methyl-2,2′-bipyridine (synthesized in the “synthesis of ligand” in Example 5) was used in place of 39. 08 mg of 4,4′ -dicarboxy-2,2′ -bipyridine used in the “synthesis of dye” in Example 5. It was found that the product was one represented by the above formula (22) by 1H-NMR analysis. 1H-NMR (DMSO-d6, 298K, 270MHz, delta(ppm)) ; delta = 9.41 (m, 1H), 9.06-8.70 (m, 5H), 8.27 (m, 1H), 7.82-7.12 (m, 5H), 2.68 (s, 3H), 2.42 (s, 3H)

103946-54-9, As the paragraph descriping shows that 103946-54-9 is playing an increasingly important role.

Reference£º
Patent; JSR Corporation; EP1767588; (2007); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103946-54-9,4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid,as a common compound, the synthetic route is as follows.

300 mg (1.4 mmol) of 4-methyl-4′-carboxy-2,2′-bipyridine was weighed out296 mg (1.64 mmol) of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (EDC ¡¤ HCl) and 161 mg (1.4 mmol) of N-hydroxysuccinimide (NHS) , Evacuated and protected by nitrogen. Then, 6 mL of dry DMF and 0.4 mL of dry triethylamine were added to react for 12 h at 25 C., 1.5 mL of ethylamine and 0.6 mL of triethylamine were added, and the reaction was continued at 25 C. for 24 h. The reaction was completed and the residue was evaporated under reduced pressure. The residue was taken up in dichloromethane (3 ¡Á 100 mL) and the organic phase was spin-dried and packed in silica gel. The product was isolated and purified in 30% yield

103946-54-9, As the paragraph descriping shows that 103946-54-9 is playing an increasingly important role.

Reference£º
Patent; Nanjing University of Posts and Telecommunications; Zhang Yin; Zhang Taiwei; Sun Guanglan; Gao Pengli; Chen Xiaojiao; Zhao Qiang; Liu Shujuan; Huang Wei; (16 pag.)CN107417737; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

103946-54-9, 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE. Peptide Synthesis. The collagen-mimetic peptide H-byp, NH2-(Pro-Hyp-Gly)4-(Pro-Lys(Mtt)-Gly)-(Pro-Hyp-Gly)4-COOH, was synthesized by standard solid phase synthesis on a rink amide Chem Matrixresin. In the manual synthesis, 3 equivalents of Fmoc-amino acids were treated with HBTU (3 equiv.) and diisopropylethylamine(DIEA) (2 equiv) in an NMP solution. For the N-terminal acetylation, the resin was treated with acetic anhydrideand DIEA in DMF for 1 hr. The Mtt protecting group was removed using as described above using 1.8% TFA in DCM.The resin was treated with 2,2?-bipyridine-4,4?-carboxylic acid (3 equiv.), HBTU (3 equiv.), and DIEA (3 equiv.) in NMP.The peptide was cleaved from the resin by treatment for 2 h with TFA/TIPS/H2O (95:2.5:2.5), followed by precipitationwith diethyl ether.

103946-54-9, As the paragraph descriping shows that 103946-54-9 is playing an increasingly important role.

Reference£º
Patent; Purdue Research Foundation; CHMIELEWSKI, Jean, A.; PIRES, Marcos, M.; PRZYBYLA, David, E.; (74 pag.)EP2300033; (2016); B1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI