Tag: 1126-58-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1126-58-5,1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: To a magnetically stirred solution of substituted isatin (5mmol) in 7ml of absolute ethanol, a corresponding pyridinium acetohydrazide (5mmol) and three drops of trifluoroacetic acid were successively added. The reaction mixture was heated under reflux for 3h. After spontaneously cooling the solution to room temperature, the precipitate formed was filtered, washed with absolute ether and dried in vacuo. (0032) 1-(2-(2-(1-(2-Fluorobenzyl)-2-oxoindolin-3-ylidene)hydrazinyl)-2-oxoethyl)pyridinium chloride (3a): yellow solid, mp: 215C (dec.). 2.08g (98% yield); 1H NMR (600MHz, DMSO-d6/D2O): delta 5.00 (s, 2H, CH2), 6.26 (s, 2H, CH2), 6.89 (d, J =8.0Hz, 1H, H-7), 7.15 (dd, J =7.6Hz, J =7.6Hz, 1H, H-5), 7.59 (ddd, J =7.7Hz, J =7.8Hz, J =1.0Hz, 1H, H-6), 7.64 (br. d, J =7.5Hz, 1H, H-4), 8.27 (dd, J =7.0Hz, J =6.7Hz, 2H, 3-Py), 8.74 (t, J =7.8Hz, 1H, 4-Py), 9.15 (d, J =5.6Hz, 2H, 2-Py), 12.71 (s. 1H, NH); 13C NMR (150MHz, DMSO-d6/D2O): delta 37.2, 61.0, 110.5, 115.6 (d, JCF =20.9Hz), 118.8, 120.7, 122.1 (d, JCF =13.5Hz), 123.5, 124.7, 127.7, 129.8 (d, JCF =2.4Hz), 130.0 (d, JCF =7.9Hz), 132.2, 134.9, 143.0, 146.5, 146.6, 160.1 (d, JCF =245.5Hz), 160.5, 167.6; IR (KBr) nu: 3430, 3033, 3015, 2968, 1681, 1614, 1492, 1466, 1383, 1358, 1267, 1154, 1104, 1044cm-1; Anal. Calcd (%) for C22H18ClFN4O2: C, 62.14; H, 4.24; N, 13.18; Found: C, 61.86; H, 4.17; N, 13.01; MALDI 389 [M-Cl]+.

As the paragraph descriping shows that 1126-58-5 is playing an increasingly important role.

Reference£º
Article; Bogdanov, Andrei V.; Zaripova, Ilyuza F.; Voloshina, Alexandra D.; Sapunova, Anastasia S.; Kulik, Natalia V.; Tsivunina, Irina V.; Dobrynin, Alexey B.; Mironov, Vladimir F.; Journal of Fluorine Chemistry; vol. 227; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1126-58-5,1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of the corresponding bis(isatin) 1-8 (5 mmol) and Girard?s reagent (2.5 mmol) in 7 mL of absolute ethanol were added three drops of trifluoroacetic acid. The reaction mixture was refluxed for 2 h. After spontaneous cooling of the solution to room temperature, the formed precipitate was filtered off, washed with absolute diethyl ether and dried in vacuum (12 mmHg).

1126-58-5 1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride 70773, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Bogdanov; Zaripova; Mustafina; Voloshina; Sapunova; Kulik; Mironov; Russian Journal of General Chemistry; vol. 89; 7; (2019); p. 1368 – 1376; Zh. Obshch. Khim.; vol. 89; 7; (2019); p. 1004 – 1012,9;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI