With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128143-88-4,[2,2′:6′,2”-Terpyridin]-4′(1’H)-one,as a common compound, the synthetic route is as follows.
A round-bottom flask containing 60mL of 1:1 ethanol/water was degassed with argon for 30min. A 0.25g (0.55mmol) sample of [Ru(tpyOH)Cl3] and a 0.20g (0.80mmol) sample of 2,6-bis(2-pyridyl)-4(1H)-pyridone was added to the reaction flask and heated to 100C for 3h. After the reaction was completed, the solution was cooled to room temperature. To the solution, 5 drops of concentrated HCl was added to ensure protonation of the hydroxyl groups. The solution was filtered to remove insoluble, unreacted reagents. To the solution, an excess of NH4PF6 in 20mL of water was added. An additional 150mL of water was added to the solution to precipitate the orange red complex. The complex was filtered and washed with water, followed by ether. No further purification was required. Yield: 0.28g (0.31mmol), 56%. 1H NMR (300MHz, CD3CN): delta 9.1 (br, 2H), 8.4(d, 4H), 8.2 (s, 4H), 7.9 (dd, 4H), 7.4 (d, 4H), 7.1 (dd, 4H). Anal. Calc. for RuC30N6O2H22P2F12: C, 40.50; N, 9.45; H, 2.50. Found: C, 40.43; N, 9.31; H, 2.48%.
The synthetic route of 128143-88-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Maghacut, Kent A.; Wood, Alessa B.; Boyko, Walter J.; Dudley, Timothy J.; Paul, Jared J.; Polyhedron; vol. 67; (2014); p. 329 – 337;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI