With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148332-36-9,[2,2′:6′,2”-Terpyridine]-4′-carboxylic acid,as a common compound, the synthetic route is as follows.
Synthesized according to the route shown in Figure 6.Taking tert-butoxycarbonylglycine (0.35 g, 2 mmol) and aminothiazole compoundTz-NH2 (0.47 g, 2 mmol),Dicyclohexylcarbodiimide DCC (0.41 g, 2 mmol),30 mL of N,N-dimethylformamide was stirred at room temperature for 3 hours.The solvent was evaporated under reduced pressure to give a white solid. The solid was dissolved in 20 mL of dichloromethane and then added with trifluoroAcetic acid (1.03 g, 9 mmol) was stirred for 1 hr. Add N,N-dimethylformamide30 mL dissolved, added tpyCOOH (0.55 g, 2 mmol), dicyclohexylcarbodiimide DCC (0.41 g, 2 mmol), 30It was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure, washed with water and dried in vacuo to give a white solid. Production volume 0.99g, yield 90percent. Precursor complex [Ru(tpy)Cl3] (0.79 g, 1.7 mmol) and ligand tpyL3 (0.99 g, 1.8)Methyl) 50 mL of ethylene glycol methyl ether and 0.5 mL of 4-ethylmorpholine were added to the flask and refluxed for 4 hours. Cool to room temperature, filter,To the filtrate was added saturated KPF6 (815 mg, 5 mmol), and the precipitate was precipitated.It was then vacuum dried to give a crude product. Chromatography on silica gel column, eluting with a mixture of acetonitrile and methanol (volume ratio 2:1)The color component gives the target terpyridine pyridinium (II) complex RuTz3. The yield was 1.43 g and the yield was 72percent., 148332-36-9
The synthetic route of 148332-36-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Yunnan University; Gao Feng; Ma Guolan; Bi Xudan; (15 pag.)CN109096339; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI