Analyzing the synthesis route of 148332-36-9

The synthetic route of 148332-36-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148332-36-9,[2,2′:6′,2”-Terpyridine]-4′-carboxylic acid,as a common compound, the synthetic route is as follows.

Synthesized according to the route shown in Figure 6.Taking tert-butoxycarbonylglycine (0.35 g, 2 mmol) and aminothiazole compoundTz-NH2 (0.47 g, 2 mmol),Dicyclohexylcarbodiimide DCC (0.41 g, 2 mmol),30 mL of N,N-dimethylformamide was stirred at room temperature for 3 hours.The solvent was evaporated under reduced pressure to give a white solid. The solid was dissolved in 20 mL of dichloromethane and then added with trifluoroAcetic acid (1.03 g, 9 mmol) was stirred for 1 hr. Add N,N-dimethylformamide30 mL dissolved, added tpyCOOH (0.55 g, 2 mmol), dicyclohexylcarbodiimide DCC (0.41 g, 2 mmol), 30It was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure, washed with water and dried in vacuo to give a white solid. Production volume 0.99g, yield 90percent. Precursor complex [Ru(tpy)Cl3] (0.79 g, 1.7 mmol) and ligand tpyL3 (0.99 g, 1.8)Methyl) 50 mL of ethylene glycol methyl ether and 0.5 mL of 4-ethylmorpholine were added to the flask and refluxed for 4 hours. Cool to room temperature, filter,To the filtrate was added saturated KPF6 (815 mg, 5 mmol), and the precipitate was precipitated.It was then vacuum dried to give a crude product. Chromatography on silica gel column, eluting with a mixture of acetonitrile and methanol (volume ratio 2:1)The color component gives the target terpyridine pyridinium (II) complex RuTz3. The yield was 1.43 g and the yield was 72percent., 148332-36-9

The synthetic route of 148332-36-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Yunnan University; Gao Feng; Ma Guolan; Bi Xudan; (15 pag.)CN109096339; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Brief introduction of 148332-36-9

The synthetic route of 148332-36-9 has been constantly updated, and we look forward to future research findings.

148332-36-9, [2,2′:6′,2”-Terpyridine]-4′-carboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.0 mmol of CuSO4 and 0.5 mmol of 2,2 ‘:6′,2″-terpyridine-4’-carboxylic acid were mixed, and placed in a stainless steel-lined stainless steel reactor. 20 mL of deionized water and 10 mL of absolute ethanol were added, mixed evenly, sealed, and hydrothermal reaction was carried out at 120-180 ¡ã C for 3 ~ 5 days under high temperature and high pressure environment to increase the reaction. The oxidation-reduction potential of the material changes significantly to improve the reaction rate. After completion of the hydrothermal reaction, the stainless steel reactor was cooled to room temperature by 5 ¡ã C per hour to obtain a blue block of 2,2 ‘: 6’, 2 ‘tripyridine-4’-carboxylic acid copper sulfate crystals. The resulting crystals were ground to 100 mesh sieve, to obtain terpyridine-4 ‘-carboxylic acid copper hydrogensulfate monoclinic blue powder having purity of not less than 99percent., 148332-36-9

The synthetic route of 148332-36-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ningbo University; Lin, Danfeng; Xu, Wei; Zhang, Beibei; Qi, Jinli; Lin, Jianli; Zhu, Honglin; Zheng, Yueqing; (7 pag.)CN103450228; (2016); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI