With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.294-90-6,1,4,7,10-Tetraazacyclododecane,as a common compound, the synthetic route is as follows.
1,4,7,10-Tetraazacyclododecane (10 mmol) was dissolved in methanol (15 ml). To the system was added triethylamine (2 ml), and then slowly dropwise added at room temperature ethyl trifluoroacetate (50 mmol). Upon the completion of dropwise addition, the mixture was allowed to react at room temperature over night, concentrated and then column separated (eluant: ethyl acetate) to obtain 4.1 g of a white solid, yield 89%, MS[M]+=460.3 m/e.
294-90-6 1,4,7,10-Tetraazacyclododecane 64963, acatalyst-ligand compound, is more and more widely used in various.
Reference£º
Patent; Beijing Molecule Science and Technology Co., Ltd.; EP2163553; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI