New learning discoveries about 29841-69-8

As the paragraph descriping shows that 29841-69-8 is playing an increasingly important role.

29841-69-8, (1S,2S)-(-)-1,2-Diphenylethylenediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.440 g (2.07 mmol) of (S,S)-DPEN (MW: 212.3) was introduced into a 100-mL three-necked flask and subjected to argon-gas replacement. 20 mL of dehydrated methylene chloride and 0.303 mL (2.17 mmol) of triethylamine were added and cooled to 0 C. To this solution, a solution consisting of 0.520 g (2.07 mmol) of 3′,5′-dimethoxyphenyl methanesulfonyl chloride (MW: 250.70) and 5 mL of dehydrated methylene chloride was slowly added dropwise, and stirred at 0 C. for 3 hr. This solution was washed twice with water, the solvent in the organic layer was distilled away, and dried under reduced pressure to give a crude product. The crude product was purified by silica-gel column chromatography (silica gel 60N, n-hexane:AcOEt=1:1, then AcOEt 100%) to give 0.51 g of (S,S)-(3′,5′-dimethoxyphenyl)methane-SO2DPEN (58% yield). 1H NMR (400 MHz, CDCl3, rt, delta/ppm): 3.59 (d, J=13.7 Hz, 1H, SO2C2C6H3), 3.64 (d, J=13.7 Hz, 1H, SO2C2C6H3), 3.71 (s, 6H, (OC3)2), 4.23 (d, J=6.4 Hz, 1H, CNH2), 4.59 (d, J=6.4 Hz, 1H, CNHSO2), 6.29 (d, J=2.3 Hz, 2H, C62H (OCH3)2), 6.36 (d, J=2.3 Hz, 1H, C6H2(OCH3)2), 7.18-7.40 (m, 10H, aromatic proton)., 29841-69-8

As the paragraph descriping shows that 29841-69-8 is playing an increasingly important role.

Reference£º
Patent; Kanto Kagaku Kabushiki Kaisha; US2010/261924; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Analyzing the synthesis route of 29841-69-8

29841-69-8, The synthetic route of 29841-69-8 has been constantly updated, and we look forward to future research findings.

29841-69-8, (1S,2S)-(-)-1,2-Diphenylethylenediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound3 (0.97g, 3 . 60mmol) dissolved in dichloromethane (10 ml), 0 C stirring, add triethylamine (0.81 ml, 5 . 85mmol) and ethyl chloroformate (0.36 ml, 3 . 82mmol), maintaining 0 C stirring 30 min, then adding (1S, 2S)-bisphenylmethyl ethylenediamin (0.47g, 2 . 25mmol), 40 C reaction 24h. After the reaction, solution concentration, column chromatography (methanol/dichloromethane = 1/45, volume ratio), vacuum drying to obtain white solid4a (1.03g, 80%).

29841-69-8, The synthetic route of 29841-69-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hubei University; Lu, Cuifen; Ren, Jun; Chen, Zuxing; Yang, Guichun; Nie, Junqi; Zhou, Yuan; (11 pag.)CN105330687; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Downstream synthetic route of 29841-69-8

As the paragraph descriping shows that 29841-69-8 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.

In a single-necked 50 mL round-bottom flask bis-aldehyde c (0.72 g, 1.5 mmol) was taken in dry MeOH (10 mL) and was stirred at 0 C, and a solution of 1S,2S-(+)-1,2-diaminocyclohexane (0.18 g,1.6 mmol)/1S, 2S-(-)-1,2-diphenylethane-1,2-diamine (0.34 g,1.6 mmol) in dry MeOH (5 mL) was added drop wise to the above solution. After complete addition, the resulting solution was further stirred at room temperature. After an interval of 12 h, solvent was completely removed under reduced pressure, and the bright yellow solid was extracted with dichloromethane (50 mL). The organic layer was washed with water (3 ¡Á 50 mL) and with brine (3 ¡Á 50 mL) and finally dried over anhydrous Na2SO4. After removal of dichloromethane under reduced pressure, the chiral ligands 1′ and 2′ purified by silica gel column chromatography (100-200 mesh) in 20% (EtOAc: Hexane) resulted in yellowish solid monomeric macrocyclic ligands, 1′ and 2′.1′: Yield 85%. m.p. 104 C. 1H NMR (500 MHz, CDCl3): delta 1.44 (18 H, s), 1.73-1.91 (8H, m), 3.23-3.25 (2H, m), 3.31-3.33 (4H, m), 3.51-3.62 (8H, m), 4.19 (2H, d, J = 11), 4.43 (2H, d, J = 11), 6.72 (2H, s), 7.27 (2H, s), 8.07 (2H, s), 11.78 (2H, br) ppm. 13C NMR (125 MHz, CDCl3): 24.3, 29.4, 32.7, 34.8, 68.5, 69.2, 70.7, 72.3, 76.4, 118.3, 127.3, 129.8, 137.4, 160.0, 166.2 ppm. FT-IR (KBr): nu 3432, 2942, 2863, 2359, 1629, 1558, 1442, 1387, 1259, 1212, 1099, 970, 845, 768, 728, 668, 594 cm-1. (c = 0.052, CH2Cl2). Anal. Calcd. for C36H52N2O6: C, 71.02; H, 8.61; N, 4.60. Found C, 71.0; H, 8.58; N, 4.58. TOF-MS (ESI+): m/z Calcd. for [C36H52N2O6] 608.81, Found 610.2 [M+H].2′: Yield 90%. m.p. 98 C. 1H NMR (200 MHz, CDCl3): delta 1.46 (18H, s), 3.30-3.36 (4H, m), 3.57-3.68 (8H, m), 4.19 (2H, d, J = 10), 4.47 (2H, d, J = 10), 4.56 (2H, s), 6.72 (2H, d, J = 1.8), 7.18-7.30 (12H, m), 8.24 (2H, s), 13.86 (2H, br) ppm. 13C NMR (50 MHz, CDCl3): 29.5, 33.9, 69.0, 70.8, 72.5, 78.6, 118.3, 127.5, 128.3, 128.4, 129.2, 137.4, 139.8, 160.1, 166.8 ppm. IR (KBr): nu 3452, 2929, 2865, 1626, 1553, 1440, 1263, 1096, 848, 726, 585, 464 cm-1. (c = 0.206, CHCl3). Anal. Calcd. for C44H54N2O6 C, 74.76; H, 7.70; N, 3.96. Found C, 74.73; H, 7.68; N, 3.93. TOF-MS (ESI+): m/z Calcd. for [C44H54N2O6] 706.91, Found 708.45 [M+H].

As the paragraph descriping shows that 29841-69-8 is playing an increasingly important role.

Reference£º
Article; Kureshy, Rukhsana I.; Roy, Tamal; Khan, Noor-Ul H.; Abdi, Sayed H.R.; Sadhukhan, Arghya; Bajaj, Hari C.; Journal of Catalysis; vol. 286; (2012); p. 41 – 50;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI