Tag: 4568-71-2

4568-71-2, 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 2 L four-necked flask equipped with a stirrer and a nitrogen gas inlet tube, 301.7 g (1.12 g) of 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride Mol), ion exchanged water 300.3 g and sodium thiocyanate 91.6 g (1.43 mol), and the mixture was stirred at room temperature for 3 hours. After completion of the stirring, the organic layer was separated from the reaction solution separated into an aqueous layer and an organic layer. After washing the organic layer three times with 300 g of ion exchanged water, it was placed in a rotary evaporator and concentrated. The obtained concentrate was dried under reduced pressure, dissolved with 157.48 g of methanol, heated to 65 ¡ã C. and recrystallized by cooling. The obtained crystals were separated by filtration and dried under reduced pressure to give 3-benzyl-5- (2-hydroxyethyl) -4-methylthiazolium thiocyanate248.97 g (yield: 76percent) was obtained.

4568-71-2 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride 2833352, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; KOEI CHEMICAL COMPANY LIMITED; TAGATA, TSUYOSHI; KAWAMICHI, TAKEHIDE; SAITO, AYA; (17 pag.)JP5814080; (2015); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4568-71-2, 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(2) beta-(4-Fluorophenyl)-alpha-(2-methyl-1-oxopropyl)-gamma-oxobenzenebutanoic acid, ethyl ester A mixture of Part (1) compound (14.59 g, 55.4 mmoles), 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride (4.484 g, 0.3 eq.) and triethylamine (5.4 mL, 0.7 eq.) was treated with benzaldehyde (1.9 mL), heated up to 70¡ã (oil bath) under argon and stirred at 70¡ã for 1.0 hour. The addition of benzaldehyde was repeated three more times (1.9 mL each), heating the mixture for 1.0 hour after each addition. The reaction mixture was cooled down to room temperature, diluted with ethyl acetate (800 mL) and washed successively with 5percent KHSO4 (150 mL), saturated sodium bicarbonate (150 mL) and brine (150 mL). The organic solution was dried (anhydrous MgSO4), filtered, evaporated to dryness and dried in vacuo . The crude product was combined with previous runs (881.6 mg and 236.5 mg) and chromatographed on a silica gel column (Merck), eluding the column with Et2O:Hexane mixtures (5:95; 1:9) to give title compound as a light yellow thick syrup (20.694 g, 98.3percent). TLC: Rf0.22 (Silica gel; Et2O:Hexane- 15:85; UV).

As the paragraph descriping shows that 4568-71-2 is playing an increasingly important role.

Reference£º
Patent; E.R. SQUIBB & SONS, INC.; EP463456; (1992); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI