Tag: 4730-54-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.

5 mmol of 1,4,7-triazacyclononane (645 mg) and benzaldehyde (508 muL, 5 mmol) were stirred at room temperature in distilled ethanol (80 mL) containing molecular sieve for 4 h. The solution was filtered and evaporated under reduced pressure to yield the aminal product as a white solid (980 mg, 4.5 mmol, 90%). NMR (CDCl3) 1H (300 MHz) 2.89-2.93 (m, 4H,CH2tacn) 2.99-3.03 (m, 2H,CH2tacn) 3.07-3.17 (m, 4H,CH2tacn) 3.32-3.39 (m, 2H,CH2tacn) 5.66 (s, 1H, Haminal) 7.18 (t, 1H, HPhe) 7.29 (t, 2H, HPhe) 7.50 (2H, d, HPhe); 13C (75 MHz) 49.3 49.6 58.8 (CH2tacn) 88.3 (Caminal) 126.6, 126.7 128.2 (CHPhe) 145.8 (CPhe).

4730-54-5, 4730-54-5 1,4,7-Triazacyclononane 188318, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Roger, Melissa; Patinec, Veronique; Tripier, Raphael; Triki, Smail; Poul, Nicolas Le; Mest, Yves Le; Inorganica Chimica Acta; vol. 417; (2014); p. 201 – 207;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.,4730-54-5

20 g of triazacyclononane trihydrochloride (83.8 mmol), 35.4 g of 1-fluoro-4-nitrobenzene (251.4 mmol) and 40 g of potassium carbonate (290 mmol) are placed in 150 ml of water and the mixture is refluxed with stirring for 24 hours. After cooling to room temperature, the orange-yellow solid obtained is filtered off and rinsed with water and then with petroleum ether. After drying, 31 g of product are obtained, i.e. a yield of 99%. The results of the analyses obtained by 1H NMR and by mass spectrometry are as follows: 1H NMR (400 MHz, DMSO): 2.2 (m, 1H); 2.8 (m, 4H); 3.4 (m, 4H); 3.9 (m, 4H); 6.8 (m, 4H); 8.1 (m, 4H). Mass (ESI+): m/z=372 (MH+).

The synthetic route of 4730-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Vidal, Laurent; Sabelle, Stephane; Ly-Carry, Thi-My; US2005/120494; (2005); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.

To a solution of acetic acid 2-acetoxy-2-[3-(allyl-methyl-carbamoyl)-5- chlorocarbonyl^Atheta-triiodo-phenylcarbamoyll-ethyl ester (17) (3.7g, 5.10mmol) in dichloromethane (2OmL) was added 1 ,4,7-triazacyclononane (200mg, 1.55mmol) followed by triethylamine (650mul_, 5.10mmol). The reaction mixture was stirred at 5O0C for 48h. After cooling to ambient temperature, ethyl acetate (5OmL) was added, and the white precipitate collected. Purification by column chromatography, eluting with ethyl acetate:methanol(10 – 50%, 12 column volumes, SiO2, 25Og) gave the desired product as an off white solid (2g, 53%). LCMS was carried out Luna C18 250 LCMS shown one major peak with a mass of 1215.83 (M/2 + H+) and a purity of 85%.

4730-54-5 1,4,7-Triazacyclononane 188318, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; GE HEALTHCARE AS; WO2008/123779; (2008); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 6a (30 mg, 0.078 mmol), 1,4,7-triazacyclononane (3.4 mg, 0.026 mmol), K2CO3 (18.1 mg, 0.13 mmol), MeCN (1.2 mL) and CH2Cl2 (0.2 mL) was stirred overnight at r.t. The solvents were evaporated and the product purified by preparative TLC (10 % EtOH/CH2Cl2 + 1 % TEA), yielding 24 mg (89 %) of the title compound.ESI-TOF-MS [M+H]+: calc. for C54H6IN6Oi5+ 1033.42, found 1033.42.

4730-54-5 1,4,7-Triazacyclononane 188318, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; WALLAC OY; WO2009/30819; (2009); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.0 g (7.8 mmol) of 1,4,7-triazacyclononane and 16.7 mL of mesitylene were supplied into a 50 mL two-necked flask equipped with a reflux condenser, and 4.8 g (27 mmol) of cyclohexylmethyl bromide and 2.2 g (39 mmol) of potassium hydroxide were added. The mixture was stirred for 72 hours at 100 C. under argon gas atmosphere. After reaction completed, salt was removed by filtration, and then the filtrate was concentrated and purified by reduced-pressure distillation. (Amount of yield 2.7 g, Yield 83%) [0092] 1H-NMR(chloroform-d,ppm):0.75-1.90(m,33H), 2.23(d,6H), 2.68(s,12H) [0093] 13C-NMR(chloroform-d,ppm):26.6, 27.3, 32.3, 36.9, 57.0, 67.0 IR(KBr method, cm-1): 2919, 2849, 2788, 1448, 1357, 1314, 1263, 1161, 1113, 1033, 997, 965, 892, 843, 792, 728 [0094] Elemental analysis/calculated value: C(77.63%), H(12.31%), N(10.06%)/observed value: C(78.02%), H(12.43%), N(9.89%) [0095] (ii) Synthesis of Cu(cHexMe3tacn): [0096] To 0.36 g (0.86 mmol) of 1,4,7-tris(cyclohexylmethyl)-1,4,7-triazacyclononane, 10 mL of dichloromethane/methanol was added to obtain a uniform solution, and then 5 mL of dichloromethane/methanol containing 0.15 g (0.88 mmol) of cupric chloride dehydrate was added. The mixture was stirred for one hour at room temperature. After reaction completed, solvent was removed in vacuum, and then the residue was recrystallized from dichloromethane/methanol. (Amount of yield 0.28 g, Yield 59%) [0097] IR(KBr method, cm-1):2929, 2922, 2916, 2849, 1496, 1447, 1106, [0098] Elemental analysis/calculated value: C(58.74%), H(9.31%), N(7.61%)/observed value: C(58.35%), H(9.25%), N(7.58%)

The synthetic route of 4730-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Higashimura, Hideyuki; Kotake, Eiichi; Kubota, Masaaki; Kobayashi, Shiro; US2004/267057; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,4,7-triazonane (129mg, 1.0 equiv) and K2CO3 (3.6 g, 10.0equiv) was dissolved in100 mL MeCN, a solution of 1c (1.16 g, 3.6 equiv) in 15 mL MeCNwas slowly added at 0 C, then the mixture was heated under gentlereflux for 48 h. The mixture was filtered and the filtrate concentrated invacuo and purified by flash column chromatograph on silica gel(dichloromethane /methanol as the eluent) to provide 2d light yellowsolid (545.9 mg, 64% yield). 1H NMR (400 MHz, MeOD): delta 7.54 (d,J = 7.4 Hz, 3H), 7.43 (dd, J = 7.8, 1.6 Hz, 6H), 7.34 (dd, J = 7.9,1.8 Hz, 9H), 6.43 (d, J = 7.4 Hz, 3H), 5.06 (s, 6H), 4.14 (t, J = 6.4 Hz,6H), 3.75 (t, J = 6.4 Hz, 6H), 2.67 (s, 12H), 2.25 (s, 9H). 13C NMR(101 MHz, MeOD): delta 179.2, 175.2, 147.4, 145.1, 141.4, 138.5, 130.2,129.4, 117.4, 74.6, 52.2, 38.7, 29.0, 12.8. ESI-MS: calculated forC51H60N6O6, [M+H] + m/z = 853.5, found 853.5.

The synthetic route of 4730-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Xiaoguang; Dong, Xiuxiu; He, Chuanchuan; Zhang, Xiaojuan; Xiang, Guangya; Ma, Xiang; Bioorganic Chemistry; vol. 96; (2020);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.

0.75 g (5.6 mmol) of 1,4,7-triazacyclononane was completely dissolved in 50 mL of ethanol, followed by 2.8 mL(20.2 mmol) triethylamine and 2.71 g (19.6 mmol) bromoacetamide, and the mixture was heated under reflux and stirred for 6 hours, then naturally cooled to room temperature, suction filtered, and the white solid obtained was vacuum dried at 35 C. to obtain the ligand represented by Formula I.

As the paragraph descriping shows that 4730-54-5 is playing an increasingly important role.

Reference£º
Patent; Shaanxi Normal University; Liu Jing; Quan Jingmiao; Lei Hairui; Yan Junlin; (8 pag.)CN104892533; (2017); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI