53344-72-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53344-72-2,6,6′-Dichloro-2,2′-bipyridine,as a common compound, the synthetic route is as follows.
General procedure: Oven-dried Schlenk flask was evacuated and backfilled with argon three times. In the stream of argon heteroaryl dichloride (1 eq), K2CO3 (3 eq) were placed thereto. Secondary phosphine oxide (2.4 eq) was dissolved in DMF (15 ml/mmol) and the solution was added to the flask. The solution was bubbled with argon for 10 min and Pd(OAc)2 (0.02 eq) and dppf (0.04 eq) were added to the flask simultaneously. The resulting mixture was heated at 80oC for 7 h and then poured into fourfold excess of brine. The mixture was extracted with CH2Cl2 three times (40 ml/mmol each). Combined organic extracts were washed with brine to remove traces of DMF, dried over anhydrous Na2SO4 and then evaporated to dryness. The residue was purified by column chromatography on silica gel 40-60 using CH2Cl2-MeOH mixture as eluent.
As the paragraph descriping shows that 53344-72-2 is playing an increasingly important role.
Reference£º
Article; Zakirova, Gladis G.; Mladentsev, Dmitrii Yu.; Borisova, Nataliya E.; Tetrahedron Letters; vol. 58; 35; (2017); p. 3415 – 3417;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI