Tag: 54761-04-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54761-04-5,Ytterbium(III) trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.,54761-04-5

4.6. Synthesis of a Complex of H3TTPTCN and Ytterbium A solution of 30.5 mg (0.05 mmol) of ytterbium triflate in 1 ml of water is admixed with a solution of 36 mg (0.05 mmol) of H3TTPTCN in 2 ml of water in which the pH is adjusted to 7 by addition of an aqueous NaOH solution. The subsequent procedure is as described in section 4.2 above. In this way a complex is isolated: [Yb(TTPTCN)].6.5H2O (yield: 30%). Elemental analysis: calculated (found): C: 33.55% (33.69%) H: 4.38% (4.37%) N: 26.08% (25.61%)

The synthetic route of 54761-04-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Giraud, Marion; Demadrille, Renaud; Mazzanti, Marinella; Andreiadis, Eugen Sorin; US2011/112289; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54761-04-5, Ytterbium(III) trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,54761-04-5

Example 6 2-(4-{3-[5-Acetyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxy-propyl}-piperazin-1-yl)-benzonitrile. A solution of 1-[1-oxiranylmethyl-3-(4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone (0.84 g, 2.30 mmol) in CH2Cl2 (10 mL) was treated with ytterbium(III) triflate (0.29 g, 0.46 mmol) and 1-(2-cyanophenyl)-piperazine (0.75 g, 3.5 mmol) at 25 C. and stirred for 48 h before it was diluted with CH2Cl2 (100 mL) and H2O (50 mL). The organic layer was separated, washed with H2O (2*50 mL), dried over Na2SO4, and concentrated. Column chromatography (silica, 5% MeOH/CH2Cl2) afforded 1.15 g (90%) of light yellow crystals. TLC (silica, 10% MeOH/CH2Cl2): Rf=0.30. MS (electrospray): m/z 553.3 ([M+H]+, C29H31F3N6O2 requires 552.3). 1H NMR (CDCl3, 400 MHz, a mixture of two rotamers): 7.82 and 7.68 (AB pattern, Jab=8.2 Hz, 2H), 7.76 and 7.72 (AB pattern, Jab=8.4 Hz, 2H), 7.60-7.48 (m, 2H), 7.05-7.00 (m, 2H), 4.90 and 4.78 (AB pattern, Jab=16 Hz, 1H), 4.69 (s, 1H), 4.30-3.71 (m, 6H), 3.25 (m, 4H), 3.02-2.75 (m, 4H), 2.70-2.65 (m, 2H), 2.60-2.53 (m, 2H), 2.23 (s, 1.5H), 2.18 (s, 1.5H).

The synthetic route of 54761-04-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Breitenbucher, J. Guy; Cai, Hui; Edwards, James P.; Grice, Cheryl A.; Gu, Yin; Gustin, Darin J.; Karlsson, Lars; Khatuya, Haripada; Meduna, Steven P.; Pio, Barbara A.; Sun, Siquan; Tays, Kevin L.; Thurmond, Robin L.; Wei, Jianmei; US2003/69240; (2003); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54761-04-5,Ytterbium(III) trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

To 5 (0.131 g, 1.0 mmol) and Yb(OTf)3 (0.124 g, 0.20 mmol) in CH2Cl2 (1.5 mL) under argon was added methyl vinyl ketone 22(0.162 mL, 2 mmol). The reaction mixture was stirred at rt overnight and concentrated in vacuo. Purification by silica gel chromatography (1:1, EtOAc:hexane, to 100%, EtOAc, as eluent) afforded 24 asa white solid (0.051 g, 25%) and 23 as a yellow oil (0.128 g, 37%): Rf.0.23 (1:1, EtOAc:methanol, as eluent); 1H NMR (700 MHz, CDCl3)d 9.12 (br s, 1H), 7.87 (dd, J7.6, 1.1 Hz, 1H), 7.72 (td, J7.6, 1.1 Hz,1H), 7.47 (td, J7.6, 1.1 Hz, 1H), 7.35 (dd, J7.6, 1.1 Hz, 1H), 4.32 (t,J6.0 Hz, 2H), 4.14 (t, J8.1 Hz, 2H), 3.29 (t, J6.0 Hz, 2H), 3.27 (t,J8.1 Hz, 2H), 2.23 (s, 3H) ppm; 13C NMR (176 MHz, CDCl3) d 206.2,168.1, 138.6, 136.4, 134.7, 128.7 (q, J285 Hz), 124.7, 121.9, 119.4,116.8, 55.6, 49.2, 40.1, 30.1, 25.5; IR nmax (thin film) 1714 (C]O),1661 (C]N) cm1; LRMS (TOF ES), 203.5 (100%) [MH], 201.7(70%), 132.1 (25%); LRMS (TOF ES-), 149.0 (100%) [OTf]; HRMS(FTMS ES) calculated for C13H15NOH, 202.12264; found202.12262; HRMS (FTMS ES-), calculated for CF3O3Se, 148.95257;found 148.95217.

54761-04-5 Ytterbium(III) trifluoromethanesulfonate 2733225, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Girling, P. Ricardo; Batsanov, Andrei S.; Calow, Adam D.J.; Shen, Hong C.; Whiting, Andrew; Tetrahedron; vol. 72; 8; (2016); p. 1105 – 1113;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54761-04-5, Ytterbium(III) trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2 Preparation of Ru(OTf)[(S,S)-Tsdpen](p-cymene) as Sulfonate Complex First, Ru[(S,S)-Tsdpen](p-cymene) (180 mg, 0.3 mmol), Yb(OTf)3 (183 mg, 0.3 mmol) (manufactured by Aldrich), and 3 ml of CH3OH were charged in a 20 ml Schlenk-type reaction tube purged with argon. Then, the resultant mixture was degassed and stirred at room temperature for 10 minutes. After CH3OH was distilled off under reduced pressure (1 mm Hg), 2 ml of THF was added to the residue, and the produced precipitate was filtered off, washed with 1 ml of THF and with 5 ml of toluene, and dried under reduced pressure (1 mmHg) to obtain 130 mg of Ru(OTf)[(S,S)-Tsdpen](p-cymene).

As the paragraph descriping shows that 54761-04-5 is playing an increasingly important role.

Reference£º
Patent; NAGOYA INDUSTRIAL SCIENCE RESEARCH INSTITUTE; US2008/234525; (2008); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI